Possible mechanisms of hyponatremia | - Increased fluid intake overwhelms hypothalamus-kidney feedback loop
- Malfunction in loop turns on continuous ADH secretion
- Receptors in kidney increase water uptake either due to ADH or independent of ADH (Angiotensin II)
- Stimulates pituitary to release ADH, which causes water retention in kidney
- Constricts blood vessels to increase blood pressure
- Stimulates adrenal gland to release aldosterone, which leads to
- Potassium wasting (hypokalemia)
- Hydrogen loss (metabolic alkalosis)
- Further water retention leading to hyponatremia
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