Type | Clinical features |
Definition and epidemiology | - Chronic inflammatory disease of colon with chronic diarrhea that is watery and non-bloody
- Can occur after age 35 and more common in women
- Subtypes (based on histologic findings)
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Associated conditions | - Oligoarticular arthritis that is nonerosive
- Possible other autoimmune diseases
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Possible etiologies | |
Possible pathophysiology | - Genetic predisposition with HLA-DR3DQ2 haplotype
- Increased collagen deposition in tissues due to increased TGF beta-1 or vascular endothelial growth factor
- Epithelial barrier dysfunction leading to increased permability of bacteria, antigens, and eventual inflammation
- Diarrhea likely due to mucosal inflammation in lamina propria
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